The Break-Up is a 2006 American romantic comedy-drama film directed by Peyton Reed, and starring Vince Vaughn and Jennifer Aniston. It was written by Jay Lavender and Jeremy Garelick from a story by them and Vaughn, and produced by Universal Pictures.

Peyton Tucker Reed is an American television and film director. He directed the comedy films Bring It On, Down with Love, The Break-Up, and Yes Man, as well as the superhero film Ant-Man and its sequels.