The Children's Museum of Indianapolis is the world's largest children's museum. It is located at 3000 North Meridian Street, Indianapolis, Indiana in the United Northwest Area neighborhood of the city. The museum is accredited by the American Alliance of Museums. It is 472,900 square feet (43,933.85 m2) with five floors of exhibit halls and receives more than one million visitors annually. Its collection of over 130,000 artifacts and exhibit items is divided into two domains: Arts & Humanities and the Natural Sciences. Among the exhibits are simulated Cretaceous and Jurassic dinosaur habitats, a carousel, a steam locomotive, and the glass sculpture Fireworks of Glass Tower and Ceiling. The museum's focus is family learning; most exhibits are designed to be interactive, allowing children and families to actively participate.

Children's museums are institutions that provide exhibits and programs to stimulate informal learning experiences for children. In contrast with traditional museums that typically have a hands-off policy regarding exhibits, children's museums feature interactive exhibits that are designed to be manipulated by children. The theory behind such exhibits is that activity can be as educational as instruction, especially in early childhood. Most children's museums are nonprofit organizations, and many are run by volunteers or by very small professional staffs.