The Danny Thomas Show is an American sitcom that ran from 1953 to 1957 on ABC and from 1957 to 1964 on CBS. Starring Danny Thomas as a successful night club entertainer, the show focused on his relationship with his family, yet went through a number of significant changes in cast and characters during the course of its run. Episodes regularly featured music by Thomas, guest stars and occasionally other cast members as part of the plot.

Danny Thomas was an American actor, singer, nightclub comedian, producer, and philanthropist. He created and starred in the Danny Thomas Show. In addition to guest roles on many of the comedy, talk, and musical variety programs of his time, his legacy includes a lifelong dedication to fundraising for charity. Most notably, he was the founder of St. Jude Children's Research Hospital in Memphis, Tennessee, a leading center in pediatric medicine with a focus on pediatric cancer. St. Jude now has affiliate hospitals in eight other American cities as of early 2020.