The Frank Sinatra Show was a title applied—in some cases specifically and in other cases generically—to several radio musical programs in the United States, some of which had other distinct titles as indicated below. Singer Frank Sinatra starred in the programs, some of which were broadcast on CBS, while others were on NBC.

Jane Powell was an American actress, singer, and dancer who appeared in Metro-Goldwyn-Mayer musicals in the 1940s and 50s. With her soprano voice and girl-next-door image, Powell appeared in films, television and on the stage, performing in the musicals A Date with Judy (1948), Royal Wedding (1951), Seven Brides for Seven Brothers (1954), and Hit the Deck (1955).