The Frank Sinatra Show was a title applied—in some cases specifically and in other cases generically—to several radio musical programs in the United States, some of which had other distinct titles as indicated below. Singer Frank Sinatra starred in the programs, some of which were broadcast on CBS, while others were on NBC.

Albert Jerome Wheeler was an American comedian who performed in Broadway theatre, American comedy feature films, and vaudeville acts. He was the comedy partner of Robert Woolsey, and together they formed a successful double act called Wheeler & Woolsey.