The George Sanders Mystery Theater is the title of a 30-minute American television mystery drama series hosted by character actor George Sanders which aired Sundays on NBC in the summer of 1957, replacing the first half of Caesar's Hour.

George Henry Sanders was a British actor and singer whose career spanned over 40 years. His heavy, upper-class English accent and smooth, baritone voice often led him to be cast as sophisticated but villainous characters. He is remembered for his roles as wicked Jack Favell in Rebecca (1940), Scott ffolliott in Foreign Correspondent, The Saran of Gaza in Samson and Delilah, theater critic Addison DeWitt in All About Eve, Sir Brian De Bois-Guilbert in Ivanhoe (1952), King Richard the Lionheart in King Richard and the Crusaders (1954), Mr. Freeze in a two-part episode of Batman (1966), and the voice of Shere Khan in Disney's The Jungle Book (1967). Fans of radio detective stories know Sanders as Simon Templar, The Saint, (1939–41), and the suave crimefighter The Falcon (1941–42).