"The Great Wife Hope" is the third episode of the twenty-first season of the American animated television series The Simpsons. Originally broadcast on the Fox network in the United States on October 11, 2009, it sees the men of Springfield taking immense interest in a new combat sport called mixed martial arts (MMA). Marge is appalled by the violent sport and demands that the creator put a stop to it, but he agrees only if she will fight him in a match and win.

The twenty-first season of the American animated television series The Simpsons aired on Fox from September 27, 2009, to May 23, 2010. It was the first of two seasons that the show was renewed for by Fox, and also the first season of the show to air entirely in high definition.