The Hotel Mouse is a musical comedy with music by Armand Vecsey and Ivan Caryll, lyrics by Clifford Grey, and book by Guy Bolton, with additional music by Bert Hanlon, and additional lyrics by Alfred Bryan. The book is based on the French comedy Le souris d'hôtel by Marcel Gerbidon and Paul Armont and concerns a female cat burglar in Monte Carlo given the nickname "the hotel mouse" by the local police; one of her marks falls in love with her.

Félix Marie Henri Tilkin, better known by his pen name Ivan Caryll, was a Belgian-born composer of operettas and Edwardian musical comedies in the English language, who made his career in London and later New York. He composed some forty musical comedies and operettas.