The House of Blue Leaves is a play by American playwright John Guare which premiered Off-Broadway in 1971, and was revived in 1986, both Off-Broadway and on Broadway, and was again revived on Broadway in 2011. The play won the Drama Critics' Circle Award for Best American Play and the Obie Award for Best American Play in 1971. The play is set in 1965, when Pope Paul VI visited New York City.

John Guare is an American playwright and screenwriter. He is best known as the author of The House of Blue Leaves and Six Degrees of Separation.