The House of the Scorpion is a 2002 science fiction young adult novel by Nancy Farmer. It is set in the future and mostly takes place in Opium, a country which separates Aztlán and the United States. The main character Matteo Alacrán, or Matt, is a young clone of a drug lord of the same name, usually called "El Patrón". It is a story about the struggle to survive as a free individual and the search for a personal identity.

“Aztlán” is the ancestral home of the Aztec peoples. Astekah is the Nahuatl word for "people from Aztlan". Aztlan is mentioned in several ethnohistorical sources dating from the colonial period, and while they each cite varying lists of the different tribal groups who participated in the migration from Aztlan to central Mexico, the Mexica who went on to found Mexico-Tenochtitlan are mentioned in all of the accounts.