The Human Stain is a novel by Philip Roth, published May 5, 2000. The book is set in Western Massachusetts in the late 1990s. Its narrator is 65-year-old author Nathan Zuckerman, who appears in several earlier Roth novels, including two books that form a loose trilogy with The Human Stain, American Pastoral (1997) and I Married a Communist (1998). Zuckerman acts largely as an observer as the complex story of the protagonist, Coleman Silk, a retired professor of classics, is slowly revealed.

Philip Milton Roth was an American novelist and short-story writer. Roth's fiction—often set in his birthplace of Newark, New Jersey—is known for its intensely autobiographical character, for philosophically and formally blurring the distinction between reality and fiction, for its "sensual, ingenious style" and for its provocative explorations of American identity. He first gained attention with the 1959 short story collection Goodbye, Columbus, which won the U.S. National Book Award for Fiction. Ten years later, he published the bestseller Portnoy's Complaint. Nathan Zuckerman, Roth's literary alter ego, narrates several of his books. A fictionalized Philip Roth narrates some of his others, such as the alternate history The Plot Against America.