The Jerusalem International Writers Festival is an annual festival that takes place at the Mishkenot Sha’ananim Cultural Center in Jerusalem, Israel. Since Mishkenot Sha’ananim opened in 1974, literature has been one of its main focuses. The Jerusalem International Writers Festival was first held in 2008 and was a biennial event until 2018, when it was decided to hold it on a yearly basis.

Mishkenot Sha'ananim was the first Jewish settlement built outside the walls of the Old City of Jerusalem, on a hill directly across Mount Zion. It was built in 1859–1860. This guesthouse was one of the first structures to be built outside the Old City, the others being Kerem Avraham, the Schneller Orphanage, Bishop Gobat school, and the Russian Compound.