The Jeselnik Offensive was an American late-night television series that aired on Comedy Central. It was hosted by stand-up comedian Anthony Jeselnik, who extended his onstage character into weekly, topical humor with a sociopathic, dark twist. The show primarily consisted of a monologue and two panelists who joined Jeselnik in adding a humorous take on shocking, lurid news stories. The series premiered February 19, 2013, on Comedy Central and was renewed for a second season on April 26, 2013, and aired July 9, 2013. On November 11, 2013, Comedy Central cancelled The Jeselnik Offensive after two seasons, due to low ratings.

Anthony Jeselnik is an American comedian, writer, actor, and producer. He is known for his dark comedy style, which emphasizes ironic misdirection, non sequiturs, biting insults, an arrogant demeanor, and a stage persona that frequently takes amoral or psychopathic stances.