The Last Word with Lawrence O'Donnell is an American weeknight news and political commentary program on MSNBC. The program airs live at 10:00 p.m. Eastern Time Monday-Friday, and is hosted by Lawrence O'Donnell from Mondays to Thursdays and relief presenters on Fridays. O'Donnell is described by MSNBC as "providing the last word on the biggest issues and most compelling stories of the day."

MSNBC is an American news-based television channel and website headquartered in New York City. It is owned by NBCUniversal — a subsidiary of Comcast — and provides news coverage and political commentary. The network produces live broadcasts for its channel from studios at 30 Rockefeller Plaza in Manhattan, New York City, and aggregates its coverage and commentary on its website, msnbc.com.