The Magazine of Fantasy & Science Fiction is a U. S. fantasy and science fiction magazine first published in 1949 by Fantasy House, a subsidiary of Lawrence Spivak's Mercury Press. Editors Anthony Boucher and J. Francis McComas had approached Spivak in the mid-1940s about creating a fantasy companion to Spivak's existing mystery title, Ellery Queen's Mystery Magazine; the first issue was titled The Magazine of Fantasy, but the decision was made to include science fiction as well as fantasy, the title was changed correspondingly with the second issue. F&SF was quite different in presentation from the existing science fiction magazines of the day, most of which were in pulp format: it had no interior illustrations, no letter column, text in a single column format, which in the opinion of science fiction historian Mike Ashley "set F&SF apart, giving it the air and authority of a superior magazine". F&SF became one of the leading magazines in the science fiction and fantasy field, with a reputation for publishing literary material and including more diverse stories than its competitors.

Well-known stories that appeared in its early years include Richard Matheson's Born of Man and Woman, Ward Moore's Bring the Jubilee, a novel of an alternative history in which the South has won the American Civil War. McComas left for health reasons in 1954, but Boucher continued as sole editor until 1958, winning the Hugo Award for Best Magazine that year, a feat his successor, Robert Mills, repeated in the next two years. Mills was responsible for publishing Flowers for Algernon by Daniel Keyes, Rogue Moon by Algis Budrys, Starship Troopers by Robert Heinlein, the first of Brian Aldiss's Hothouse stories; the first few issues featured cover art by George Salter, Mercury Press's art director, but other artists soon began to appear, including Chesley Bonestell, Kelly Freas, Ed Emshwiller. In 1962, Mills was succeeded as editor by Avram Davidson; when Davidson left at the end of 1964, Joseph Ferman, who had bought the magazine from Spivak in 1954, took over as editor, though his son Edward soon began doing the editorial work under his father's supervision.

At the start of 1966 Edward Ferman was listed as editor, four years he acquired the magazine from his father and moved the editorial offices to his house in Connecticut. Ferman remained editor for over 25 years, published many well-received stories, including Fritz Leiber's "Ill Met in Lankhmar", Robert Silverberg's "Born with the Dead", Stephen King's The Dark Tower series. In 1991 he turned the editorship over to Kristine Kathryn Rusch, who began including more horror and dark fantasy than had appeared under Ferman. In the mid-1990s circulation began to decline. Gordon Van Gelder replaced Rusch in 1997, bought the magazine from Ferman in 2001, but circulation continued to fall, by 2011 it was below 15,000. Charles Coleman Finlay took over from Van Gelder as editor in 2015; the first magazine dedicated to fantasy, Weird Tales, appeared in 1923. By the end of the 1930s, the genre was flourishing in the United States, nearly twenty new sf and fantasy titles appearing between 1938 and 1941; these were all pulp magazines, which meant that despite the occasional high-quality story, most of the magazines presented badly written fiction and were regarded as trash by many readers.

In 1941, Ellery Queen's Mystery Magazine appeared, edited by Fred Dannay and focusing on detective fiction. The magazine was published in digest format, rather than pulp, printed a mixture of classic stories and fresh material. Dannay attempted to avoid the sensationalist fiction appearing in the pulps, soon made the magazine a success. In the early 1940s Anthony Boucher, a successful writer of fantasy and sf and of mystery stories, got to know Dannay through his work on the Ellery Queen radio show. Boucher knew J. Francis McComas, an editor who shared his interest in fantasy and SF. By 1944 McComas and Boucher became interested in the idea of a fantasy companion to Ellery Queen's Mystery Magazine, spoke to Dannay about it. Dannay was interested in the idea, but paper was scarce because of World War II; the following year Boucher and McComas suggested that the new magazine could use the Ellery Queen name, but Dannay knew little about fantasy and suggested instead that they approach Lawrence Spivak, the owner of Mercury Press, which published Ellery Queen's Mystery Magazine.

In January 1946, Boucher and McComas went to New York and met with Spivak, who let them know in the year that he wanted to go ahead. At Spivak's request they began acquiring material for the new magazine, including a new story by Raymond Chandler, reprint rights to stories by H. P. Lovecraft, John Dickson Carr, Robert Bloch. Spivak planned the first issue for early 1947, but delayed the launch because of poor newsstand sales of digest magazines, he suggested that it should be priced at 35 cents an issue, higher than the original plan, to provide a financial buffer against poor sales. In May 1949 Spivak suggested a new title, The Magazine of Fantasy, in August a press release announced that the magazine would appear in October. On October 6, 1949, Boucher and McComas held a luncheon at the Waldorf-Astoria in New York City to commemorate the 100th anniversary of the death of Edgar Allan Poe and to launch "a new fantasy anthology periodical". Invitees included Carr, Basil Rathbone, Boris Karloff.

The first issue, published by Fantasy House, a subsidiary of American Mercury, sold 57,00

Crow kinship is a kinship system used to define family. Identified by Lewis Henry Morgan in his 1871 work Systems of Consanguinity and Affinity of the Human Family, the Crow system is one of the six major kinship systems; the system is somewhat similar to the Iroquois system, but distinguishes between the mother's side and the father's side. Relatives on the mother's side of the family have more descriptive terms, relatives on the father's side have more classificatory terms; the Crow system is distinctive because unlike most other kinship systems, it chooses not to distinguish between certain generations. The relatives of the subject's father's matrilineage are distinguished only by their sex, regardless of their age or generation. In contrast, within Ego's own matrilineage, differences of generation are noted; the system is associated with groups. In doing so, the system is a mirror image of the Omaha system, patrilineal; as with the Iroquois system, the Crow uses bifurcate merging, meaning that there is a distinction between collateral relatives of different gender in Ego's descent group.

In this case, father's brother would be called "father's brother", mother's brother would be called "uncle". Only the Iroquois system uses BM as a secondary name; the system is named for the Crow Tribe of Montana. The system appears among various cultures. In the Southwestern US, it has traditionally been part of the Hopi Indian culture and the Navajo Nation. Family Kinship and descent Anthropology List of anthropologists William Haviland, Cultural Anthropology, Wadsworth Publishing, 2002. ISBN 0-534-27479-X Thomas Trautmann and Peter M. Whiteley, Crow-Omaha: new light on a classic problem of kinship analysis, University of Arizona Press, 2012. ISBN 978-0-8165-0790-0 The nature of kinship Archnet: Crow kinship Crow Kin Terms "Crow Kinship & Social Organization", University of Idaho

Katafygio is a village in Aetolia-Acarnania in Greece. It is built amphitheatrically at an altitude of 620 metres on the Eastern foothills of Makryoro Mountain, naked and steep, it borders to the north with Anavriti village, north-east with Kentriki and Aspria villages, southeast with Chrysovo village, northwest with Gavros village and southwest with Anthofyto village. It is about 33 kilometres from Nafpaktos and is accessed by a tarmac road via Nafpaκtos - Anthofyto - Gavros - Golemi and after passing through the imposing rocks of Amorani; the village is surrounded by 2 hills on the summits of which are found the small churches of St Konstantinos and St Athanasios. The village is divided into 4 equal parts by 4 streams that join towards the lower part of the village; the land here is prone to landslip. In 1878, 25 buildings disappeared because of subsidence; the houses and the fields are strengthened with low walls. In the centre of village is the square with 2 coffee houses and the Holy Church of Koimiseos of Theotokou.

In the village there are 2 basketball courts, a children's playground, while at the top of village in the place named Desi there is a traditional hostel called Desi, in the entrance of the village in the place named Saint Dimitrios there is another one called Katafigio. The natural environment itself constitutes a beautiful sight, it is worth climbing the gorge of Foniorema, visiting the old mills, the caves, the 2 old traditional bridges which are located in pretty settings. The Holy Church of "Metamorphosis of Sotiros" ), built about 13th century and situated near Chrysovo; this church is what remains of the historic monastery of Sotiros which at that time belonged to Amorani, and, closed in 1834. The old name of the village was Amorani. In 1928, it was renamed Katafygio; the new name of the village resulted from the fact that at the time of the Ottoman occupation the area represented a genuine refuge. The abundance of caverns, the rocky and steep terrain rendered the village exceptionally inaccessible.

It is not certain when it was founded, however it exists as a village round 1550–1575, at which time we find it registered in Turkish tax documents in the region of Kravara. During the period of Ottoman domination it constituted one of the main villages of the region. Around 1700 two families of cattle-breeders moved home to the western side of the Makryoro mountain and created a small settlement, named Golemi; this historical relationship renders Golemi an integral part of Katafygio. Administratively Katafygio village from 1836. With the royal decree in 31 August 1912 261/Α/1912 it was recognized as the community of Amorani, it was renamed to Katafygio by the decree of 9 September 1927 of the official Journal of the Hellenic Republic 206/A/1927. Included in the community is the small settlement of Golemi. With the application of the Kapodistria law it constitutes henceforth the Municipal District of Katafygio, in the Municipality of Apodotia in Aetolia-Acarnania, Greece and it occupies 23.429 stremmata, while the census of 2011 recorded 322 individuals making it one of the more vibrant villages of the mountainous Nafpaktia area.

The residents lived by livestock farming, maintaining a significant number of animals, an activity which the remaining residents still carry on today. Katafigio Nafpaktias Katafigio - Amorani

A serotonin–dopamine reuptake inhibitor is a type of drug which acts as a reuptake inhibitor of the monoamine neurotransmitters serotonin and dopamine by blocking the actions of the serotonin transporter and dopamine transporter, respectively. This in turn leads to increased extracellular concentrations of serotonin and dopamine, therefore, an increase in serotonergic and dopaminergic neurotransmission. A related type of drug is a serotonin–dopamine releasing agent. Relative to serotonin–norepinephrine–dopamine reuptake inhibitors, which inhibit the reuptake of norepinephrine in addition to serotonin and dopamine, SDRIs might be expected to have a reduced incidence of certain side effects, namely insomnia, appetite loss and heart rate and blood pressure changes. Unlike the case of other combination monoamine reuptake inhibitors such as serotonin–norepinephrine reuptake inhibitors and norepinephrine–dopamine reuptake inhibitors, on account of the similar chemical structures of their substrates, it is exceptionally difficult to tease apart affinity for the DAT from the norepinephrine transporter and inhibit the reuptake of dopamine alone.

As a result, selective dopamine reuptake inhibitors are rare, comparably, SDRIs are more so. Medifoxamine is an antidepressant that appears to act as an SDRI as well as a 5-HT2 receptor antagonist. Sibutramine is a withdrawn anorectic that itself as a molecule in vitro is an SNDRI but preferentially an SDRI, with 18.3- and 5.8-fold preference for inhibiting the reuptake of serotonin and dopamine over norepinephrine, respectively. However, the metabolites of sibutramine are more potent and possess different ratios of monoamine reuptake inhibition in comparison, sibutramine appears to be acting in vivo as a prodrug to them. Sertraline is a selective serotonin reuptake inhibitor, uniquely among most antidepressants, it shows high affinity for the DAT as well; as such, it has been suggested that clinically it may weakly inhibit the reuptake of dopamine at high dosages. For this reason, sertraline has sometimes been described as an SDRI; this is relevant as dopamine is thought to be involved in the pathophysiology of depression, increased dopaminergic signaling by sertraline in addition to serotonin may have additional benefits against depression.

Tatsumi et al. found Ki values of sertraline at the SERT, DAT, NET of 0.29, 25, 420 nM, respectively. The selectivity of sertraline for the SERT over the DAT was 86-fold. In any case, of the wide assortment of antidepressants assessed in the study, sertraline showed the highest affinity of them all for the DAT higher than the norepinephrine–dopamine reuptake inhibitors nomifensine and bupropion. Sertraline is said to have similar affinity for the DAT as the NDRI methylphenidate, it is notable that tametraline, a close analogue of sertraline and the compound from which sertraline was derived, is an NDRI, never marketed. Single doses of 50 to 200 mg sertraline have been found to result in peak plasma concentrations of 20 to 55 ng/mL, while chronic treatment with 200 mg/day sertraline, the maximum recommended dosage, has been found to result in maximal plasma levels of 118 to 166 ng/mL. However, sertraline is protein-bound in plasma, with a bound fraction of 98.5%. Hence, only 1.5 % is theoretically bioactive.

Based on this percentage, free concentrations of sertraline would be 2.49 ng/mL at the most, only about one-third of the Ki value that Tatsumi et al. found with sertraline at the DAT. A high dosage of sertraline of 400 mg/day has been found to produce peak plasma concentrations of about 250 ng/mL; this can be estimated to result in a free concentration of 3.75 ng/mL, still only about half of the Ki of sertraline for the DAT. As such, it seems unlikely that sertraline would produce much inhibition of dopamine reuptake at clinically used dosages well in excess of the recommended maximum clinical dosage; this is in accordance with its 86-fold selectivity for the SERT over the DAT and hence the fact that nearly 100-fold higher levels of sertraline would be necessary to inhibit dopamine reuptake. In accordance, while sertraline has low abuse potential and may be aversive at clinical dosages, a case report of sertraline abuse described dopaminergic-like effects such as euphoria, mental overactivity, hallucinations only at a dosage 56 times the normal maximum and 224 times the normal minimum.

For these reasons, significant inhibition of dopamine reuptake by sertraline at clinical dosages is controversial, occupation by sertraline of the DAT is thought by many experts to not be clinically relevant. Two SDRIs that are known in research at present are RTI-83 and UWA-101, though other related compounds are known. Based on its chemical structure, UWA-101 may also possess some activity as a releasing agent, if so, unlike RTI-83, it would not be an SDRI in the purest sense and would be an SDRA. Manning et al. presented two high-affinity MAT-ligands with good binding selectivity for SERT and DAT, namely the 4-indolyl and 1-naphthyl arylalkylamines ent-16b and ent-13b respectively. AN-788 is another SDRI, has been under development for the treatment of depressive and anxiety disorders. Mo

William Angus was an English engraver of copper plates for prints and book illustrations. William Angus was born in 1752, he became a master engraver. Among his pupils was the engraver William Bernard Cooke, he died in Islington, Middlesex in 1821. Brough Hall, seat of Sir John Lawson Castle Howard Cusworth, seat of William Wrightson Sand Beck, seat of the Earl of Scarborough Thomas Paine, 1791 Newnham Court in Oxfordshire, the Seat of Earl Harecourt, 1795

Jesse David Royal is a Jamaican reggae musician. Jesse Royal was born in Jamaica to a family of Maroon ancestry and Rasta faith; the Royal family relocated to Kingston in 1997 to accept a job at a telecom company, where Jesse became friends with Daniel Bambata Marley, son of reggae artist Ziggy Marley. Royal began his career with and was mentored by the late Fatis Burrell, who produced Jesse's first two releases, Singing the Blues and Long Days and Short Nights in 2010 Jesse Royal has toured extensively in Jamaica as well as Europe and the United States, before releasing his first major work produced by his friend Walshy Fire in 2014. In 2015, Vogue Magazine listed Jesse Royal as part of a greater ongoing "Reggae Revival" movement happening in Jamaica and the rest of the world, revitalising the genre of roots reggae. In 2016 he featured on the Ragin fyah album in a song called Humble In 2017 he recorded the album Lily of da Valley, released by Easy Star Records in October; the album topped the Billboard Reggae Albums chart.

"Butterflies" "This Morning" "Gimme Likkle" "Modern Day Judas" "Finally" "Feel Your Pain" "Generation" "We Matter" "Weight On Your Shoulders" "Glad To Be" "LionOrder" Misheni - DJ Tall Up In Comes the Small Axe'- DJ Tall Up Major Lazer's Walshy Fire Presents - Royally Speaking Mixtape Hope & Love Lily of da Valley, Easy Star Official Facebook page