The Mark & Brian Show was an American radio talk show hosted by Mark Thompson and Brian Phelps, known on the air as "Mark & Brian." The syndicated program aired weekday mornings from KLOS-FM in Los Angeles, California, and blended comedy sketches, listener phone calls, interviews with in-studio guests, and the occasional road trip. At the peak of its popularity, the show was syndicated to 21 other markets in the western US, including San Francisco, Honolulu, Portland Oregon, and Tucson Arizona.

KLOS is a commercial radio station that is licensed to Los Angeles, California, and serves the Greater Los Angeles area. The station is owned by Meruelo Media. KLOS airs a mainstream rock radio format and has broadcast rock music in some form since 1969. The studios are on West Olive Avenue in Burbank.