The Most Serene Republic is a Canadian indie rock music group formed in 2003 in Milton, Ontario. The band takes its name from the sobriquet of Venice under the Doges, which was regarded as "The Most Serene Republic of Venice".

Milton is a town in Southern Ontario, Canada, and part of the Halton Region in the Greater Toronto Area. Between 2001 and 2011, Milton was the fastest growing municipality in Canada, with a 71.4% increase in population from 2001 to 2006 and another 56.5% increase from 2006 to 2011. In 2016, Milton's census population was 110,128 with an estimated growth to 228,000 by 2031. It remained the fastest growing community in Ontario but was deemed to be the sixth fastest growing in Canada at that time.