The fifth and final season of The New Adventures of Old Christine was renewed on April 22, 2009 and announcing in May to be the final season that premiered on CBS on Wednesday nights at 8:00 PM on September 23, 2009 and concluded on May 12, 2010. It consisted of 21 episodes.

The New Adventures of Old Christine is an American sitcom starring Julia Louis-Dreyfus as Christine Campbell, a divorced mother doing her best to keep pace with those around her. Clark Gregg co-starred as her ex-husband Richard, with whom Christine maintains a close relationship despite their divorce, as well as Hamish Linklater as her brother Matthew and Wanda Sykes as her best friend, Barb. It ran on CBS from March 13, 2006 to May 12, 2010.