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The New England Journal of Medicine

The New England Journal of Medicine is a weekly medical journal published by the Massachusetts Medical Society. It is among the most prestigious peer-reviewed medical journals as well as the oldest continuously published one. In September 1811, John Collins Warren, a Boston physician, along with James Jackson, submitted a formal prospectus to establish the New England Journal of Medicine and Surgery and Collateral Branches of Science as a medical and philosophical journal. Subsequently, the first issue of the New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science was published in January 1812; the journal was published quarterly. On April 29, 1823, another publication, the Boston Medical Intelligencer, appeared under the stewardship of Jerome V. C. Smith; the Intelligencer ran into financial troubles in the spring of 1827, the editors of the New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science purchased it in February 1828 merging the two publications to form the Boston Medical and Surgical Journal, published weekly.

In 1921, the Massachusetts Medical Society purchased the Journal for US$1 and, in 1928, renamed it to The New England Journal of Medicine. The journal's logo depicts the Rod of Asclepius crossed over a quill pen; the dates on the logo represent the founding of the components of The New England Journal of Medicine: 1812 for the New England Journal of Medicine and Surgery and Collateral Branches of Medical Science, 1823 for the Boston Medical Intelligencer, 1828 for the Boston Medical and Surgical Journal, 1928 for the New England Journal of Medicine. Notable articles from the course of The New England Journal of Medicine's history include: In November 1846, Henry Jacob Bigelow, a Boston surgeon, reported a breakthrough in the search for surgical anesthetics with the first uses of inhaled ether in 1846; this allowed patients to remain sedated during operations ranging from dental extraction to amputation. "A patient has been rendered insensible during an amputation of the thigh, regain consciousness after a short interval," Bigelow wrote.

"Other severe operations have been performed without the knowledge of the patients." In June 1906, James Homer Wright published an article that described how he stained and studied bone marrow with descriptions of what are now known as megakaryocytes and platelets. In October 1872, a lecture by C. E. Brown-Séquard was published that proposed the then-revolutionary idea that one cerebral hemisphere can influence both sides of the body; the neurologist would go on to describe. In June 1948, Sidney Farber reported promising results in treatment of early childhood leukemia. Based on anecdotal evidence that children with acute leukemia worsened if they were given folic acid, he worked on blocking folic acid metabolism, his team gave 16 infants and children with acute lymphoblastic leukemia a folic acid inhibitor, aminopterin—10 showed improvement by clinical and hematologic parameters after three months. In his article, Farber advised receiving the results cautiously: "It is again emphasized that these remissions are temporary in character and that the substance is toxic and may be productive of greater disturbances than have been encountered so far in our studies," he wrote.

"No evidence has been mentioned in this report that would justify the suggestion of the term'cure' of acute leukemia in children." In November 1952, cardiologist Paul Zoll published an early report on resuscitation of the heart. "The purpose of this report is to describe the successful use in 2 patients of a quick, simple and safe method of arousing the heart from ventricular standstill by an artificial, electric pacemaker," he wrote. "For the first time it was possible to keep a patient alive during ventricular asystole lasting for hours to days. This procedure may prove valuable in many clinical situations." In February 1973, NEJM published the first report of polyp removal using a colonoscope and introduced a procedure during screening to reduce cancer risk. The authors reported from whom they removed 303 polyps. A letter published in the NEJM in 1980 was described by the journal as having been "heavily and uncritically cited" to claim that addiction due to use of opioids was rare, its publication in such an authoritative journal was used by pharmaceutical companies to push widespread use of opioid drugs, leading to an addiction crisis in the U.

S. and other countries. In December 1981, two landmark articles described the clinical course of four patients—first reported in the CDC's June 1981 Morbidity and Mortality Weekly Report—with the disease that would come to be known as AIDS. In April 2001, Druker et al. reported a targeted therapy for chronic myelogenous leukemia. Based on the knowledge that BCR-ABL, a constitutively activated tyrosine kinase, causes CML, the authors tested with success an inhibitor of this tyrosine kinase in patients who had failed first-line therapy; the finding helped begin the era of designing cancer drugs to target specific molecular abnormalities. On April 25, 1996, the NEJM announced a new web site, which published each week the abstracts for research articles and the full text of editorials and letters to the editor. After print publishing for 184 years this was the NEJM's first use of the Internet for electronic publication; the site was launched several months earlier in 1996, but the editors wanted proof that weekly electronic publication would work.

Only was an announcement approved for publication on the editorial page. Two years online publication extended to include the full text of all articles. Since its launch, NEJM has added to its site: Videos in Clin

451st Expeditionary Sustainment Command

The 451st Expeditionary Sustainment Command is a subordinate command of 79th Sustainment Support Command. The Army Reserve placed the 451st ESC in a two-year "carrier status" to allow the Army Reserve the necessary time to recruit soldiers, equip the unit and begin training to meet its activation date. Located in Wichita, Kansas the 451st ESC activated on 16 September 2011, becoming the newest ESC in the Army Reserve. In October 2012, the 451st took command and control of multiple Army Reserve units throughout the Midwest; as of 2017 the following units are subordinated to the 451st Sustainment Command: 451st Sustainment Command, in Wichita, Kansas 89th Sustainment Brigade, in Kansas City, Missouri 561st Regional Support Group, in Elkhorn, Nebraska 451 Sustainment Command Home Page U. S. Army Reserve to Begin Building New Unit in Wichita, Kansas Wichita Biz Journal: New Army Reserve unit coming to Wichita

Erol G├╝ney

Erol Güney was a Turkish-Israeli journalist and author. He is known for translating Western classics into Turkish in the 1940s, including those of Fyodor Dostoyevsky, Anton Chekhov and Molière, he was deported from Turkey in the 1950s due to an article that he wrote about the Soviet Union and emigrated to Israel in 1956, where he lived until his death in 2009. Güney was born Misha Rottenberg in Odessa, to a Ukrainian Jewish family, his family emigrated to Turkey following the October Revolution in 1917. He studied philosophy at Istanbul University. During this time, he changed his name to Erol Güney. In the 1940s, he joined a translation bureau led by then-Minister of Education Hasan Âli Yücel and Sabahattin Ali. Güney, fluent in Turkish, Russian and French, translated various works of Western literature, including Chekhov's The Cherry Orchard and Gogol's The Government Inspector. During his time at the translation bureau, he befriended important figures of Turkish literature, including Sabahattin Eyüboğlu, Azra Erhat, Cahit Külebi, Orhan Veli Kanık, Necati Cumalı, Melih Cevdet Anday.

Following the demise of Turkey's single party period and Hasan Âli Yücel's resignation, the translation bureau lost its function and Güney left it to focus on journalism. He began working for Agence France-Presse. In 1955, he was exiled to Yozgat due to an article, his Turkish citizenship was revoked and he was deported to France. In 1956, he settled in Tel Aviv. Güney continued to work as a journalist in Israel, he started writing for the Istanbul-based Jewish newspaper Şalom. He became Yedioth Ahronoth's Washington, D. C. correspondent in the 1980s. He was blacklisted from entering Turkey until 1990. Güney was married to Dora Güney. Both were close friends of poet Orhan Veli Kanık, who dedicated a well-known poem cycle to Güney and his cat, Edibe, he had a daughter, from a Parisian woman. Güney died in Tel Aviv in 2009. Oral, Haluk and M. Şeref Özsoy. Erol Güney’in Kedisi / Göçmen-Çevirmen-Gazeteci-Sevgili. Istanbul: Yapı Kredi Yayınları. ISBN 9750808924. Yaşamın Sürüklediği Yerde- Erol Güney’in Yaşam Öyküsü, a documentary by Sabiha Bânu Yalkut-Breddermann Erol Güney's obituary at Şalom

Mickey's Not-So-Scary Halloween Party

Mickey's Not-So-Scary Halloween Party is a separate-admission Halloween-themed event held annually during the months of August and October at the Magic Kingdom theme park of the Walt Disney World Resort in Lake Buena Vista, near Orlando, at Disneyland Paris Resort outside Paris, France. The party began as a response to the Halloween Horror Nights event at Universal Studios Florida. Disney's event caters to a traditional family atmosphere, whereas Universal's has more of a "fright-centered" event with their monsters The event encourages guests to dress up in Halloween costumes and celebrate the season with themed events throughout the park. Normal rules prohibit guests over the age of fourteen years from dressing in costume. On party nights, the party begins at 7 p.m. but guests can enter Magic Kingdom with just their party ticket beginning at 4 p.m. The event takes place at the Magic Kingdom during mid- August and late-October/early- November; the dates for 2019 run from August 16 until November 1.

The 2019 event is dedicated in memory of Disney Legend and long-serving voice actress. Unlike regular hours, the events include trick-or-treating throughout the Magic Kingdom with special treat locations being identified by large inflatable towers. All of the locations are indicated on the party map. Candy, handed out includes those from the Mars' Wrigley family of candy. Guests are provided a small trick-or-treat bag when they arrive, you can bring your own if you prefer. A stage show and meet-and-greet with animated Disney Villains led by Dr. Facilier titled The Disney Villains Mix and Mingle, was held at the Cinderella Castle Forecourt Stage. After the show, the villains dispersed to different areas of the park for meet and greet opportunities; the show ended in 2014. The following year, a new stage show titled Hocus Pocus Villain Spelltacular debuted in the same venue with the Sanderson Sisters from Hocus Pocus, as well as appearances from other Disney Villains including Dr. Facilier, Oogie Boogie, Maleficent.

As is the norm at Disney theme parks, a parade and a fireworks show are the centerpieces of the event. The holiday-themed parade, entitled "Mickey's Boo To You Halloween Parade," features a pre-parade ride by the Headless Horseman from The Legend of Sleepy Hollow; the parade features various Disney characters in Halloween costumes and a live-action version of the three hitchhiking ghosts from the Haunted Mansion attraction. The villains are in the parade with a unit of their own. Besides the Haunted Mansion dancers, Hitchhiking Ghosts, the hoedown dancers, the barn unit, the parade and soundtrack were changed in 2005. In 2019, additional updates to the parade were made, including the addition of two new Tomorrowland-themed floats and a new spectral bride from the Haunted Mansion. During the second parade, Cruella's Halloween Hideaway is available for an additional charge; this "party within a party" comes with reserved parade viewing plus themed savory and sweet food items and both alcoholic and non-alcoholic beverages.

The nighttime fireworks show, presented in lieu of the regular nightly show Happily Ever After, is titled Disney’s Not So Spooky Spectacular!, which debuted in August 2019. The show features fireworks, projection mapping and searchlights at Cinderella Castle, stars Jack Skellington, Mickey Mouse, Minnie Mouse, Donald Duck, Goofy; the current show serves as a replacement for Happy HalloWishes: A Grim Grinning Ghosts' Spooktacular in the Sky, based on the Haunted Mansion and featured dark music from the Disney library of animated films. Prior to that show's debut in 2005, a revival of the classic fireworks show, Fantasy in the Sky, was shown along with a three-minute holiday-themed finale featuring the Old Witch form Snow White and the seven dwarfs as the host of this Finale; the soundtrack for both the fireworks and parade are available on an in-park CD as of 2008 titled "Magic Kingdom Event Party Music", which includes music from Mickey's Pirate and Princess Party. During the fireworks, a special dessert party is available for an additional fee.

This dessert party provides guests with reserved viewing of the fireworks along with themed treats and desserts. For the first time a Not-So-Scary Halloween Party took place outside the USA in 2008. In October 2008, Disneyland Paris hosted "Mickey's Not-So-Scary Halloween Party". Streetmospheres and Meet'n'Greet with Disney Characters gave the Park a special and spooky atmosphere. For the second year, Disneyland Paris hosted once again four of these family-centered events on October 9, 16, 23, 27, 2009; the first rumors announced a wider area than the previous year, a new Villain Show could take place on the Central Hub Stage. The idea of these events remains to bring more families to the park during their annual Halloween events w

Starocherkassk Cathedral

The Military Cathedral of Christ's Resurrection was built between 1706 and 1719 as the first stone church in the Lower Don region. It was the main Christian shrine of the Don Cossack Host in the 18th century, it is situated in the stanitsa of Rostov Oblast, Russia. In 1650, during the siege of Azov, the defending Cossacks vowed to build a wooden cathedral on the square where the cossack leaders held assemblies; because of frequent fires in Cherkassk, the cathedral burned twice. The stone cathedral had been being built from 1706 to 1719, it was constructed in contrary with Peter I's decree banning the construction of stone buildings anywhere except for St. Petersburg. However, in view of political necessity, Peter himself contributed to construction works, helping with money and gifting utensils, is said to have taken a symbolic part in the process of construction, putting a few bricks on the plaster, it is believed that the main construction works were carried out by architects from Moscow, who were specially sent by the Tsar.

Moreover, it is known that the temple was built on a swamp: "Quenched the quagmire with booth and oak forest." Resurrection Cathedral has a height of 49 metres. It was built in the Cossack Baroque style by an unknown architect. Near the temple there was constructed a 48-meter high bell tower; the interior of the cathedral is striking in its decoration, which appears to be in contrast with the austere exterior. The unique five-tiered gilded iconostasis with the size of 19x23 meter contains 149 icons from the 18th century, which were painted by Moscow iconographer Egor Ivanov Grek. In front of medium-sized doors of the cathedral there is hanging a copper five-tiered chandelier, which weighs more than 550 kg, it is believed. In large semi-circular windows surrounding the Cathedral gallery used to stand cannons aimed at steppe; when Cherkassk was the capital of Don Cossacks, the storerooms of the cathedral were used to keep the regalia of Cossacks. Near the entrance to the cathedral one can see walled massive chains, in, chained Stepan Razin before he had been sent to be executed.

Close to the chains, in the gallery, there is kept ashes of Ataman Kirill Yakovlev, who treacherously betrayed his godson Stepan to government forces. Near the cathedral there is a two-tiered bell tower with the height of 45.8 meters. It is the only building of its kind in South Russia; the bell tower is transferred to Starocherkassk Don monastery. Шадрина А. В. Когда Старочеркасский воскресенский храм стал собором // Донской временник. Год 2016-й / Дон. гос. публ. б-ка. Ростов-на-Дону, 2015. Вып. 24. С. 98-101. Кирьянова С. А. Иконописец Егор Грек и иконостас Воскресенского собора Старочеркасска // Донской временник. Год 2016-й / Дон. гос. публ. б-ка. Ростов-на-Дону, 2015. Вып. 24. С. 102-106

Rancho Santa Margarita, California

Rancho Santa Margarita is a city in Orange County, United States. One of Orange County's youngest cities, Rancho Santa Margarita is a master-planned community; the population was 47,853 at the 2010 census, up from 47,214 at the 2000 census. Although it is named for Rancho Santa Margarita y Las Flores, in San Diego County, the city limits fall within the borders of Rancho Mission Viejo. At 20 characters long, it is the longest city name in California; the city seal has the brands of Rancho Mission Viejo and Rancho Santa Margarita and Las Flores on the border, with artwork containing Santiago Peak in the background. The tower in the foreground symbolizes the Rancho Santa Margarita Lake Tower. Hughes Aircraft Company's Microelectronic Systems Division moved to Rancho Santa Margarita in May 1988 from Irvine. In August 1992, the Hughes plant closed its facilities and moved the division to Carlsbad, California due to budget constraints in the aerospace industry. Rolling Hills Estates had the longest city name in California with 19 letters until January 1, 2000, when the title was ceded to Rancho Santa Margarita upon the latter's incorporation.

The City operates under the council-manager form of government. Rancho Santa Margarita is a contract city. Police services are provided through contract with the Orange County Sheriff. Fire Protection services are provided through the Orange County Fire Authority. Rancho Santa Margarita is located at 33°38′29″N 117°35′40″W, it occupies much of a high plateau known as Plano Trabuco. According to the United States Census Bureau, the city has a total area of 13.0 square miles. 13.0 square miles of it is land and 0.04 square miles of it is water. Rancho Santa Margarita is bordered by the city of Mission Viejo on the west, the census-designated Coto de Caza and Las Flores on the south, Trabuco Canyon on the north, the Cleveland National Forest on the east. Vehicular access is provided by California State Route 241, in addition to several surface streets; the majority of the neighborhoods in Rancho Santa Margarita are maintained by larger homeowners associations including SAMLARC, Dove Canyon, Rancho Cielo, Robinson Ranch, Trabuco Highlands.

Dove Canyon, Trabuco Highlands, Robinson Ranch, Rancho Cielo were all established before Rancho Santa Margarita was an incorporated community. East of Plano Trabuco Road is designated with a Trabuco Canyon zip code though the area falls within the City of Rancho Santa Margarita boundary. Rancho Santa Margarita, like most of southern California has a Mediterranean climate. According to the City's 2010 Comprehensive Annual Financial Report, the top 10 employers in the city are: ǂ As of June 2015 The 2010 United States Census reported that Rancho Santa Margarita had a population of 47,853; the population density was 3,683.1 people per square mile. The racial makeup of Rancho Santa Margarita was 37,421 White, 887 African American, 182 Native American, 4,350 Asian, 102 Pacific Islander, 2,674 from other races, 2,237 from two or more races. Hispanic or Latino of any race were 8,902 persons. 31.8% of the population possessed a bachelor's degree, with 16.4% possessing a Graduate or Professional Degree.

The educational attainment level in Rancho Santa Margarita exceeds the averages throughout the rest of California. The Census reported that 47,851 people lived in households, 2 lived in non-institutionalized group quarters, 0 were institutionalized. There were 16,665 households, out of which 7,699 had children under the age of 18 living in them, 10,144 were opposite-sex married couples living together, 1,703 had a female householder with no husband present, 700 had a male householder with no wife present. There were 747 unmarried opposite-sex partnerships, 103 same-sex married couples or partnerships. 3,199 households were made up of individuals and 761 had someone living alone, 65 years of age or older. The average household size was 2.87. There were 12,547 families; the population was spread out with 13,879 people under the age of 18, 3,793 people aged 18 to 24, 13,706 people aged 25 to 44, 13,764 people aged 45 to 64, 2,711 people who were 65 years of age or older. The median age was 36.0 years.

For every 100 females, there were 95.6 males. For every 100 females age 18 and over, there were 92.1 males. There were 17,260 housing units at an average density of 1,328.4 per square mile, of which 11,906 were owner-occupied, 4,759 were occupied by renters. The homeowner vacancy rate was 1.2%. 35,737 people lived in owner-occupied housing units and 12,114 people lived in rental housing units. During 2009–2013, Rancho Santa Margarita had a median household income of $104,113, with 3.9% of the population living below the federal poverty line. In the California State Legislature, Rancho Santa Margarita is in the 36th Senate District, represented by Republican Patricia Bates, in the 73rd Assembly District, represented by Republican Bill Brough. In the United States House of Representatives, Rancho Santa Margarita is in California's 45th congressional district, represented by Democrat Katie Porter. According to the California Secretary of State, as of February 10, 2019, Rancho Santa Margarita has 28,462 registered voters.

Of those, 11,877 are registered Republicans, 7,511 are registered Democrats, 7,819 hav