The Orson Welles Show (1941–42), also known as The Orson Welles Theater, Orson Welles and his Mercury Theater and the Lady Esther Show, was a live CBS Radio series produced, directed and hosted by Orson Welles. Broadcast Mondays at 10 p.m. ET, it made its debut September 15, 1941. Its last broadcast was February 2, 1942.

George Orson Welles was an American director, actor, writer, producer, and magician who is remembered for his innovative work in film, radio, and theatre. He is considered to be among the greatest and most influential filmmakers of all time.