The Return of Doctor Mabuse is a 1961 black-and-white crime film/thriller made in West Berlin. It was a West German/French/Italian international co-production directed by Harald Reinl that was the second of the 1960s CCC Films Dr. Mabuse film series, being the sequel to Fritz Lang's The Thousand Eyes of Dr. Mabuse (1960). It starred Gert Fröbe, Daliah Lavi and in his first German film, Lex Barker. The film was co-written by Ladislas Fodor and in his first screenplay, Marc Behm who gives the film a science fictional plot that would be followed in the other films in the series.

Harald Reinl was an Austrian film director. He is known for the films he made based on Edgar Wallace and Karl May books and also made mountain films, Heimatfilms, German war films and entries in such popular German film series as Dr. Mabuse, Jerry Cotton and Kommissar X. His directing output includes more than 60 titles. With his Edgar Wallace and Karl May adaptations, Reinl advanced to become one of the most successful directors in German cinema in the 1960s: with the four Karl May films he made between 1962 and 1965 alone, Reinl reached 32 million viewers.