The Sensational Spider-Man is a comic book series starring Spider-Man and published monthly by Marvel Comics for 41 issues between 2004 and 2007. It was originally published under the Marvel Knights imprint.

Marvel Knights is an imprint of Marvel Comics that contained standalone material taking place inside the Marvel Universe (Earth-616). The imprint originated in 1998 when Marvel outsourced four titles to Joe Quesada and Jimmy Palmiotti's company Event Comics; Event hired the creative teams for the Knights line while Marvel published them.