"The Sidewinder Sleeps Tonite" is a song by American alternative rock band R.E.M. It was influenced by the song "The Lion Sleeps Tonight", both in the title of the song and through the song's opening refrain. The band used "The Lion Sleeps Tonight" as the B-side to this song in the U.S. The song was released on R.E.M.'s 1992 album, Automatic for the People, and was later released as a single in February 1993, reaching number one in Iceland, number 13 in Ireland, number 17 in the United Kingdom, and number 29 in New Zealand. Its music video was directed by Kevin Kerslake.

"The Lion Sleeps Tonight" is a song originally written and first recorded in 1939 by Solomon Linda under the title "Mbube", through South African Gallo Record Company. Lyrics of Linda's original version were written in Zulu, while those of the English one were later written by George David Weiss.