The Smothers Brothers Show is an American fantasy sitcom featuring the Smothers Brothers that aired on CBS on Friday nights at 9:30 p.m. ET from September 17, 1965, to April 22, 1966, co-sponsored by Alberto-Culver's VO5 hairdressing products and American Tobacco's Tareyton cigarettes. It was the first television show to feature the Smothers Brothers as regulars, following a series of night club and guest appearances. It lasted one season, consisting of 32 episodes.

The Smothers Brothers were a duo of American folk singers, musicians, and comedians consisting of siblings Tom and Dick Smothers. The brothers' trademark double act was performing folk songs, which usually led to arguments between them. Tommy's signature line was "Mom always liked you best!" Tommy acted "slow" and Dick, the straight man, acted "superior".