The Sot-Weed Factor is a 1960 novel by the American writer John Barth. The novel marks the beginning of Barth's literary postmodernism. The Sot-Weed Factor takes its title from the poem The Sot-Weed Factor: Or, a Voyage to Maryland. A Satyr (1708) by the English-born poet Ebenezer Cooke, about whom few biographical details are known.

John Simmons Barth was an American writer best known for his postmodern and metafictional fiction. His most highly regarded and influential works were published in the 1960s, and include The Sot-Weed Factor, a whimsical retelling of Maryland's colonial history; Giles Goat-Boy, a satirical fantasy in which a university is a microcosm of the Cold War world; and Lost in the Funhouse, a self-referential and experimental collection of short stories. He was co-recipient of the National Book Award in 1973 for his episodic novel Chimera.