The Tale of Despereaux is a 2008 animated adventure comedy film directed by Sam Fell and Rob Stevenhagen. It is based on the 2003 novel of the same name by Kate DiCamillo. The film is narrated by Sigourney Weaver and stars Matthew Broderick, Robbie Coltrane, Dustin Hoffman, Richard Jenkins, Kevin Kline, Frank Langella, William H. Macy, Tracey Ullman, Emma Watson and Ciarán Hinds. Animation was provided by Framestore Animation.

The Tale of Despereaux is a 2003 children's fantasy book by American writer Kate DiCamillo. The main plot follows the adventures of a mouse named Despereaux Tilling, as he sets out on his quest to rescue a beautiful human princess from the rats. The book won the 2004 Newbery Medal award and has been adapted into a film, a video game, and a stage musical.