The Trouble with Physics: The Rise of String Theory, the Fall of a Science, and What Comes Next is a 2006 book by the theoretical physicist Lee Smolin about the problems with string theory. The book strongly criticizes string theory and its prominence in contemporary theoretical physics, on the grounds that string theory has yet to come up with a single prediction that can be verified using any technology that is likely to be feasible within our lifetimes. Smolin also focuses on the difficulties faced by research in quantum gravity, and by current efforts to come up with a theory explaining all four fundamental interactions. The book is broadly concerned with the role of controversy and diversity of approaches in scientific processes and ethics.

Lee Smolin is an American theoretical physicist, a faculty member at the Perimeter Institute for Theoretical Physics, an adjunct professor of physics at the University of Waterloo, and a member of the graduate faculty of the philosophy department at the University of Toronto. Smolin's 2006 book The Trouble with Physics criticized string theory as a viable scientific theory. He has made contributions to quantum gravity theory, in particular the approach known as loop quantum gravity. He advocates that the two primary approaches to quantum gravity, loop quantum gravity and string theory, can be reconciled as different aspects of the same underlying theory. He also advocates an alternative view on space and time that he calls temporal naturalism. His research interests also include cosmology, elementary particle theory, the foundations of quantum mechanics, and theoretical biology.