The Ultimate Fighter: Team Hughes vs. Team Serra was the sixth season of the Ultimate Fighting Championship (UFC) produced reality television series The Ultimate Fighter, and premiered on September 19, 2007, on Spike TV, after UFC Fight Night 11. This season featured only welterweight fighters. The teams were coached by current UFC welterweight champion Matt Serra and former welterweight champion Matt Hughes. The coaches were to fight for the welterweight title after the completion of the show, on December 29 at UFC 79. However, due to an injury sustained by Serra, Hughes instead faced former welterweight champion Georges St-Pierre for the interim title, with St-Pierre defeating Hughes by submission in the second round and going on to challenge Serra for the undisputed welterweight title at UFC 83.

The Ultimate Fighter is an American reality television series and mixed martial arts (MMA) competition produced by the Ultimate Fighting Championship (UFC) and Pilgrim Media Group currently airing on ESPN+. It previously aired for fourteen seasons on Spike TV. The show features professional MMA fighters living together in Las Vegas, Nevada, and follows them as they train and compete against each other for a prized six-figure contract with the UFC. The series debuted on January 17, 2004, with its first episode, "The Quest Begins". To date, there have been thirty one seasons of the show, two per calendar year, some years having only one season. Each season features either one or two weight classes in the tournament.