The Wire

The Wire is an American crime drama television series created and written by author and former police reporter David Simon. The series was broadcast by the cable network HBO in the United States; the Wire premiered on June 2, 2002 and ended on March 9, 2008, comprising 60 episodes over five seasons. Set and produced in Baltimore, The Wire introduces a different institution of the city and its relationship to law enforcement in each season, while retaining characters and advancing storylines from previous seasons; the five subjects are, in chronological order: the illegal drug trade, the seaport system, the city government and bureaucracy and schools, the print news medium. The large cast consists of actors who are little known for their other roles, as well as numerous real-life Baltimore and Maryland figures in guest and recurring roles. Simon has said that despite its framing as a crime drama, the show is "really about the American city, about how we live together. It's about. Whether one is a cop, a longshoreman, a drug dealer, a politician, a judge or a lawyer, all are compromised and must contend with whatever institution to which they are committed."The Wire is lauded for its literary themes, its uncommonly accurate exploration of society and politics, its realistic portrayal of urban life.

Although during its original run the series received only average ratings and never won any major television awards, it is now regarded to be one of the greatest television shows of all time. Simon has stated that he set out to create a police drama loosely based on the experiences of his writing partner Ed Burns, a former homicide detective and public school teacher who had worked with Simon on projects including The Corner. Burns, when working on protracted investigations of violent drug dealers using surveillance technology, had been frustrated by the bureaucracy of the Baltimore Police Department. Simon chose to set the show in Baltimore because of his familiarity with the city. During his time as a writer and producer for the NBC program Homicide: Life on the Street, based on his book Homicide: A Year on the Killing Streets set in Baltimore, Simon had come into conflict with NBC network executives who were displeased by the show's pessimism. Simon wanted to avoid a repeat of these conflicts and chose to take The Wire to HBO, because of their working relationship from the miniseries The Corner.

HBO was doubtful about including a police drama in its lineup but agreed to produce the pilot episode. Simon approached the mayor of Baltimore, telling him that he wanted to give a bleak portrayal of certain aspects of the city, he hoped the show would change the opinions of some viewers but said that it was unlikely to affect the issues it portrays. The casting of the show has been praised for avoiding big-name stars and using character actors who appear natural in their roles; the looks of the cast as a whole have been described as defying TV expectations by presenting a true range of humanity on screen. Most of the cast is consistent with the demographics of Baltimore. Wendell Pierce, who plays Detective Bunk Moreland, was the first actor to be cast. Dominic West, who won the ostensible lead role of Detective Jimmy McNulty, sent in a tape he recorded the night before the audition's deadline of him playing out a scene by himself. Lance Reddick received the role of Cedric Daniels after auditioning for the roles of Bunk and heroin addict, Bubbles.

Michael K. Williams got the part of Omar Little after only a single audition. Williams himself recommended Felicia Pearson for the role of Snoop after meeting her at a local Baltimore bar, shortly after she had served prison time for an attempted murder conviction. Several prominent real-life Baltimore figures, including former Maryland Governor Robert L. Ehrlich Jr.. "Little Melvin" Williams, a Baltimore drug lord arrested in the 1980s by an investigation that Burns had been part of, had a recurring role as a deacon beginning in the third season. Jay Landsman, a longtime police officer who inspired the character of the same name, played Lieutenant Dennis Mello. Baltimore police commander Gary D'Addario served as the series technical advisor for the first two seasons and has a recurring role as prosecutor Gary DiPasquale. Simon shadowed D'Addario's shift when researching his book Homicide: A Year on the Killing Streets and both D'Addario and Landsman are subjects of the book. More than a dozen cast members appeared on HBO's first hour-long drama Oz. J. D. Williams, Seth Gilliam, Lance Reddick, Reg E. Cathey were featured in prominent roles in Oz, while a number of other notable stars of The Wire, including Wood Harris, Frankie Faison, John Doman, Clarke Peters, Domenick Lombardozzi, Michael Hyatt, Michael Potts, Method Man appeared in at least one episode of Oz.

Cast members Erik Dellums, Peter Gerety, Clark Johnson, Clayton LeBouef, Toni Lewis and Callie Thorne appeared on Homicide: Life on the Street, the earlier and award-winning network television series based on Simon's book. A number of cast members, as well as crew members appeared in the preceding HBO miniseries The Corner including Clarke Peters, Reg E. Cathey, Lance Reddick, Corey Parker Robinson, Robert F. Chew, Del

St. Regis Museum Tower

St. Regis Museum Tower is a 42-story, 484 ft skyscraper in the South of Market district of San Francisco, adjacent to Yerba Buena Gardens, Moscone Center, PacBell Building and the San Francisco Museum of Modern Art; the tower is bounded by Mission Street and 3rd Street, is operated by St. Regis Hotels & Resorts; the hotel has five-star status. The tower was designed by Skidmore and Merrill and constructed by Webcor Builders with Architectural Glass and Aluminum serving on the job at the Glazing Contractor. Construction began on the highrise sometime around 2001; the project was completed in 2005 along with the retrofit of the historic nine-story Williams Building, incorporated into the tower. The tower houses 102 luxury condominiums, 269 hotel rooms, a 4-story subterranean parking garage, the Museum of the African Diaspora, its many prominent tenants led Fortune magazine to call the building "home to one of the bigger groups of power players in the world."The St. Regis Museum Tower is one of several new 21st century highrise projects completed or under construction on Mission Street, including 555 Mission Street, The Paramount, 101 Second Street, JP MorganChase Building, 301 Mission Street.

It is in the San Francisco Unified School District and is within the Daniel Webster Elementary School attendance area. InterContinental Hotel San Francisco Four Seasons W Hotel San Francisco List of tallest buildings in San Francisco

Chromatographic response function

Chromatographic response function abbreviated to CRF, is a coefficient which measures the quality of the separation in the result of a chromatography. The CRF concept have been created during the development of separation optimization, to compare the quality of many simulated or real chromatographic separations. Many CRFs have been discussed. In high performance liquid chromatography the CRF is calculated from various parameters of the peaks of solutes are considered into the calculation. In TLC the CRFs are based on the placement of the spots, measured as RF values; the CRFs in thin layer chromatography characterize the equal-spreading of the spots. The ideal case, when the RF of the spots are uniformly distributed in <0,1> range should be characterized as the best situation possible. The simplest criteria are Δ R F product, they are product of such differences. Another function is the multispot response function as developed by De al.. It is based of differences product; this function always lies between 0 and 1.

When two RF values are equal, it is equal to 0, when all RF values are equal-spread, it is equal to 1. The L and U values – upper and lower limit of RF – give possibility to avoid the band region. M R F = ∏ i = 1 n − 1 n + 1 The last example of coefficient sensitive to minimal distance between spots is Retention distance R D = 1 n The second group are criteria insensitive for minimal difference between RF values, they are equal to zero in equal-spread state increase. There are: Separation response D = ∑ i = 1 n Performance index I p = ∑ 2 n Informational entropy s m = ∑ 2 n + 1 Retention uniformity R U = 1 − 6 n ∑ i = 1 n 2 {\displaystyle R_=1-{\sqrt {{\frac