The seventh season of the American science fiction television series The X-Files commenced airing on the Fox network in the United States on November 7, 1999, concluded on May 21, 2000, and consists of twenty-two episodes. Taking place after the destruction of the Syndicate, this season marks the end of various other story lines; during this season, Fox Mulder learned the true fate of his sister, Samantha.

Samantha Ann Mulder is a fictional character in the television series The X-Files. She is the younger sister of FBI Special Agent Fox Mulder and the daughter of Teena and Bill Mulder. As a child, Samantha was abducted, ostensibly by aliens, and was never returned. It is this experience that drives her older brother Fox Mulder to join the FBI, and later take the reins of the X-Files section.