The Third Avenue–149th Street station is a station on the IRT White Plains Road Line of the New York City Subway. It is located at Third Avenue and East 149th Street in the Hub in the South Bronx adjacent to Mott Haven and Melrose. The station is served by the 2 train at all times and the 5 train at all times except nights. The station is the second-busiest in the Bronx and 59th overall, with around 6.768 million passengers using the station as of 2019.

The White Plains Road Line is a rapid transit line of the A Division of the New York City Subway serving the central Bronx. It is mostly elevated and served both subway and elevated trains until 1952. The original part of the line, the part opened as part of the first subway was called the West Farms Division, and the extension north to 241st Street as part of the Dual Contracts was called the White Plains Road Line. Eventually, however, the two parts came to be known as the White Plains Road Line.