As O. Panneerselvam who was Chief Minister from 2 March 2002 resigned, Governor appointed J. Jayalalithaa as the Chief Minister to head the New Government and appointed 26 more ministers on the same day. It was her return to power as she had removed from the post earlier on 21 September 2001.

M. Karunanidhi was sworn in as Chief Minister of Tamil Nadu on for fifth time after DMK and allies' victory in the 2006 state assembly election, forming the first minority government in the state since the 1952 election. M. Karunanidhi became the 14th Chief Minister of Tamil Nadu due to the election.