Thokottu is a commercial junction to the south of Mangalore city on National Highway 66 and the gateway to Mangalore city from the South (Kerala). It is one of the major and busiest junctions of Mangalore city wherein one road goes towards east to Deralakatte and Konaje, educational hubs with several premium educational institutions and few information technology companies, the other road towards west goes to Ullal. This junction connects Mangalore city, second major city of Karnataka with Talapady and Kerala. A flyover is constructed in the junction to reduce the congestion for the travellers travelling between Mangalore city and Kerala. The creation of educational institutions in Deralakatte and Konaje has led to the construction of many commercial complexes in the area.

National Highway 66, commonly referred to as NH 66, is a mostly 4 lane 1640 km long busy National Highway that runs roughly north–south along the western coast of India, parallel to the Western Ghats. It connects Panvel, a city east of Mumbai to Cape Comorin (Kanyakumari), passing through the states of Maharashtra, Goa, Karnataka, Kerala and Tamil Nadu.