Thomas Dermer was a 17th-century navigator and explorer. Thomas Dermer explored the eastern coastline of America from 1614 to 1620. He was associated with Captain John Smith, The Newfoundland Company, Sir Ferdinando Gorges, Jamestown, The Plymouth Company, and The Merchant Adventurers. Dermer, working side by side with Squanto, is credited with starting to normalize the relations between the Native Americans and Europeans. He was known to the Pilgrims from copies of his letters, that they had obtained. The Pilgrim colony directly benefited from the diplomatic ground work of Dermer and Squanto.

Cuper's Cove, on the southwest shore of Conception Bay on Newfoundland's Avalon Peninsula was an early English settlement in the New World, and the third one after Harbour Grace, Newfoundland (1583) and Jamestown, Virginia (1607) to endure for longer than a year. It was established in 1610 by John Guy on behalf of Bristol's Society of Merchant Venturers, who had been given a charter by King James I of England to establish a colony on the island of Newfoundland. Most of the settlers left in the 1620s, but apparently a few stayed on and the site was continuously inhabited.