Sir Thomas Hill Easterfield was born in Doncaster the youngest of four children of Edward Easterfield, savings bank secretary, and Susan. He attended Doncaster Grammar School, and later entered the Yorkshire College of Science, now the University of Leeds. He was then appointed a Senior Foundation Scholar of Clare College, Cambridge, from where he gained First Class honours in the Natural Sciences Tripos in 1886.

Cannabinol (CBN) is a mildly psychoactive cannabinoid that acts as a low affinity partial agonist at both CB1 and CB2 receptors. This activity at CB1 and CB2 receptors constitutes interaction of CBN with the endocannabinoid system (ECS).