Thomas Talbot was an American textile mill owner and politician from Massachusetts, United States. Talbot ran a major textile business, involving chemical dyeworks and the weaving of fabric, in Billerica that was a major local employer. As a Republican, he served in the state legislature, on the Massachusetts Governor's Council, and as the 29th lieutenant governor before serving for one partial term as acting governor of Massachusetts, and later for one full term as the 31st governor.

The lieutenant governor of Massachusetts is the first in the line to discharge the powers and duties of the office of governor following the incapacitation of the Governor of Massachusetts. The constitutional honorific title for the office is His, or Her, Honor.