The Thomas Viaduct spans the Patapsco River and Patapsco Valley between Relay, Maryland and Elkridge, Maryland, USA. It was commissioned by the Baltimore and Ohio Railroad (B&O); built between July 4, 1833, and July 4, 1835; and named for Philip E. Thomas, the company's first president. Some claim it to be the world's oldest multiple arched stone railroad bridge. However, the Sankey Viaduct on the Liverpool and Manchester Railway was opened in 1830 and finally completed in 1833.

The Patapsco River mainstem is a 39-mile (63 km) river in central Maryland that flows into the Chesapeake Bay. The river's tidal portion forms the harbor for the city of Baltimore. With its South Branch, the Patapsco forms the northern border of Howard County, Maryland. The name "Patapsco" is derived from the Algonquian pota-psk-ut, which translates to "backwater" or "tide covered with froth".