The Thomas Wolfe House, also known as the Thomas Wolfe Memorial, is a state historic site, historic house and museum located at 52 North Market Street in downtown Asheville, North Carolina. The American author Thomas Wolfe (1900–1938) lived in the home during his boyhood. The house was designated a National Historic Landmark in 1971 for its association with Wolfe. It is located in the Downtown Asheville Historic District.

Thomas Clayton Wolfe was an American writer. The Encyclopedia of Twentieth-Century Fiction states that "Wolfe was a major American novelist of the first half of the twentieth century, whose longterm reputation rests largely on the impact of his first novel, Look Homeward, Angel (1929), and on the short fiction that appeared during the last years of his life." Along with William Faulkner, he is considered one of the two most important authors of the Southern Renaissance within the American literary canon. He remains an important writer in modern American literature, as one of the first masters of autobiographical fiction, and is considered among North Carolina's most famous writers.