The Thompson Home is a Victorian structure located at 4756 Cass Avenue in Midtown Detroit, Michigan. Originally the Thompson Home for Old Ladies, it was constructed in 1884, designated a Michigan State Historic Site in 1974, and listed on the National Register of Historic Places in 1976.

Midtown Detroit is a commercial and residential district located along the east and west side of Woodward Avenue, north of Downtown Detroit, and south of the New Center area. The area includes several historic districts. In addition, it contains a residential area of some 14,550 people and covers 2.09 sq mi. The community area of neighborhoods is bounded by the Chrysler Freeway (I-75) on the east, the Lodge Freeway (M-10) on the west, the Edsel Ford Freeway (I-94) on the north, and the Fisher Freeway (I-75) on the south.