Thousand Oaks Boulevard, previously known as Ventura Boulevard, is a street in the Conejo Valley, Ventura County. It stretches from Thousand Oaks through Westlake Village to Agoura Hills. In Thousand Oaks, it is located in the downtown area and was also known as Main Street until the Moorpark Freeway was completed in the 1960s. Today it remains one of the busiest commercial areas in Thousand Oaks, although many businesses are also located at The Oaks and Janss Marketplace. It is Thousand Oaks’ major east-west thoroughfare, connecting The Oaks mall on the west to Thousand Oaks Civic Arts Plaza in the east. It runs parallel to the Ventura Freeway. As of 2017, over 230 businesses are housed on Thousand Oaks Boulevard.

The Conejo Valley is a region spanning both southeastern Ventura County and northwestern Los Angeles County in Southern California, United States. It is located in the northwestern part of the Greater Los Angeles Area.