The Thurgood Marshall United States Courthouse is a 37-story courthouse at 40 Centre Street on Foley Square in the Civic Center neighborhood of Lower Manhattan in New York City, United States. Opened in 1936, the building was designed by Cass Gilbert and his son, Cass Gilbert Jr., in the Classical Revival style. The United States Court of Appeals for the Second Circuit and the United States District Court for the Southern District of New York hear cases in the courthouse, which is across the street from the Metropolitan Correctional Center, New York City. It is listed on the National Register of Historic Places and is a New York City designated landmark.

Centre Street is a north–south street in the New York City borough of Manhattan, running through the Civic Center, Chinatown, and Little Italy neighborhoods of Lower Manhattan. It connects Park Row to the south with Spring Street to the north, where it merges with Lafayette Street. Centre Street carries northbound traffic north of Reade Street and two-way traffic between Reade Street and the Brooklyn Bridge.