The Tiber is the third-longest river in Italy and the longest in Central Italy, rising in the Apennine Mountains in Emilia-Romagna and flowing 406 km (252 mi) through Tuscany, Umbria, and Lazio, where it is joined by the River Aniene, to the Tyrrhenian Sea, between Ostia and Fiumicino. It drains a basin estimated at 17,375 km2 (6,709 sq mi). The river has achieved lasting fame as the main watercourse of the city of Rome, which was founded on its eastern banks.

Central Italy is one of the five official statistical regions of Italy used by the National Institute of Statistics (ISTAT), a first-level NUTS region, and a European Parliament constituency.