Tiberius was Byzantine co-emperor from 659 to 681. He was the son of Constans II and Fausta, who was elevated in 659, before his father departed for Italy. After the death of Constans, Tiberius' brother Constantine IV, ascended the throne as senior emperor. Constantine attempted to have both Tiberius and Heraclius removed as co-emperors, which sparked a popular revolt, in 681. Constantine ended the revolt by promising to accede to the demands of the rebels, sending them home, but bringing their leaders into Constantinople. Once there, Constantine had them executed, then imprisoned Tiberius and Heraclius and had them mutilated, after which point they disappear from history.

Constans II, nicknamed "the Bearded", was the Byzantine emperor from 641 to 668. Constans was the last attested emperor to serve as consul, in 642, although the office continued to exist until the reign of Leo VI the Wise. His religious policy saw him steering a middle line in disputes between the Orthodoxy and Monothelitism by refusing to persecute either and prohibited discussion of the natures of Jesus Christ under the Type of Constans in 648. His reign coincided with Muslim invasions under, Umar, Uthman, and Mu'awiya I in the late 640s to 660s. Constans was the first emperor to visit Rome since the fall of the Western Roman Empire in 476, and the last one to visit Rome while it was still held by the Empire.