Tilford is for the most part a wooded village centred at the point where the two branches of the River Wey merge in Surrey, England, 3 miles south-east of Farnham. It has half of Charleshill, Elstead in its east, a steep northern outcrop of the Greensand Ridge at Crooksbury Hill on Crooksbury Common in the north and Farnham Common Nature Reserve in the west, which has the Rural Life Centre; as the Greensand Ridge in its western section is in two parts, the Greensand Way has a connecting spur here to its main route running east–west to the south. The name "Tilford" appears to identify the Old English name Tila, as Tila's ford" or "Tilla's ford"; the two medieval bridges spanning the River Wey are Scheduled Ancient Monuments. Several substantial farm houses date from the 16th century. Tilford House was built in 1727 and its chapel in 1776. In the mid eighteenth century the village was owned by daughter of Lady Mary Abney. During the second world war, Cdr D J L'Tim' Foster, who lived in the village, brought back from northern Russia a reindeer in his submarine HMS Tigris.

The land reaches 163m OD on the boundary with Seale, with a marked 180° south-facing panorama on OS maps and other guides, taking in much of Alice Holt Forest and the Greensand Ridge. This has contributed to the inclusion wholesale of Tilford into the Surrey Hills Area of Outstanding Natural Beauty The centre of the parish on the River Wey is at 49-50m OD; the village centres on a triangular green used for cricket in the summer. The two branches of River Wey, Wey North and Wey South have their confluence in the village centre; the Barley Mow pub was built in about 1763 Tilford Oak The Tilford Institute was built in 1894 to Sir Edwin Lutyens' design and is a focus for sport. South Bank Cottage was home for 8 years from 1885 to Henry Shakspear Stephens Salt the writer and campaigner for social reform in the fields of prisons, economic institutions, the treatment of animals, it was Salt. The Rural Life Centre is a collection of prehistoric and medieval artefacts and reconstructed rural buildings.

The annual Weyfest music festival takes place here. Crooksbury House, now divided was built in Queen Anne style in 1890, enlarged in 1898-9 and changed to Arts and Crafts movement'vernacular' architecture in 1914 as Sir Edwin Lutyens's first Country House, for W. A. Chapman, its garden with a pergola is by Gertrude Jekyll and landscaped in 1892 and 1902. Mubarak Mosque was inaugurated on 17 May 2019 and serves as the headquarters of the worldwide Ahmadiyya Muslim Community; the Caliph of the community, his holiness, Hadhrat Mirza Masroor Ahmad, leads the prayers at this Mosque. Beside the green is the Tilford Oak. In the early 21st century the tree was estimated to be at least 800 years old. In 1908 Eric Parker wrote about the Tilford Oak in Highways and Byways in Surrey: William Cobbett made a curious mistake about the Tilford Oak, he and his son were riding through Tilford to Farnham on an autumn day in 1822:—"We veered a little to the left after we came to Tilford, at which place on the Green we stopped to look at an oak tree, when I was a little boy, was but a little tree and, now, take it altogether, by far the finest tree that I saw in my life.

The stem or shaft is short. Out of the stem there come not less than fifteen or sixteen limbs, many of which are from five to ten feet round, each of which would, in fact, be considered a decent stick of timber. I am not judge enough of timber to say anything about the quantity in the whole tree, but my son stepped the ground, and, as nearly as we could judge, the diameter of the extent of the branches was upwards of ninety feet, which would make a circumference of about three hundred feet; the tree is in full growth at this moment. There is a little hole in one of the limbs. I could not reach to measure it ten feet from the ground, it was not much less when Cobbett was a little boy. That independent, combative mind would not accept another's measurements, if he remembered the tree as a little tree a little tree he was right in remembering. Since his day the signs of decay have set in. Centuries hence the sapling will be the King's Oak again. Parker found it to be 1 foot more; the tree's branches have been lopped in recent years and the trunk is patched with iron sheets.

There are three other "British Oaks" nearby, planted at each corner of the triangular green, to commemorate: 60 years of Queen Victoria's reign the coronation of King Edward VII the accession of King George V – this oak was uprooted in the Great Storm of 1987 and has been replaced. All Saints Church was built in 1867 in medieval style, it is grade II listed. The Tilford Bach Festival is based at the church. Islamabad, a piece of land, bought and used for the Annual Conventions of the Ahmadiyya Community from 1985 up until 2004, when the conventions moved to Hadeeqatul Mahdi near Alton, Hampshire. In 2015 it was announced that the existing pre-fab huts on the land were intended to be replaced, with a new mosque b

Ishak Bey Kraloğlu, christened Sigismund Tomašević, was a Bosnian prince, the last known member of the House of Kotromanić and an Ottoman statesman. He was captured during the Ottoman conquest of Bosnia in 1463, after which he converted to Islam and became a companion of Mehmed the Conqueror rising to the post of sanjak-bey. Sigismund was born into the House of Kotromanić, the Bosnian royal dynasty, as the son of King Thomas and his second wife, Queen Catherine; the King notified the authorities of the Republic of Ragusa of the birth of a son in 1449, most referring to Sigismund. His birth was followed by that of Catherine. Sigismund had half-siblings born of the canonically invalid first marriage of his father. Sigismund's maternal family may have been poised to claim the crown for him, but it was his older half-brother Stephen who became King of Bosnia following the death of their father in July 1461. Sigismund's maternal grandfather, Stjepan Vukčić Kosača, the kingdom's most powerful magnate, realized that Bosnia needed an adult monarch due to the imminent threat of Ottoman conquest, refrained from pressing Sigismund's claim.

Although said to have resided at the castle of Kozograd above Fojnica with his sister and mother during King Stephen's reign, it seems unlikely that the King would not have wanted his half-siblings at his side, at the royal court in Jajce – since Sigismund was seen as heir presumptive. The Ottomans invaded Bosnia in May 1463; the royal family intended to confuse and mislead them by splitting and fleeing towards Croatia and the coast in different directions. Sigismund and his sister, separated from their mother, fell captives in the town of Zvečaj, near Jajce; the King surrendered in Ključ and was executed shortly afterwards, while Queen Catherine succeeded in escaping to the coast. She left her husband's silver sword in Ragusa and instructed the authorities to hand it over to Sigismund, should he be "liberated from Turkish captivity". Having settled in Rome, she continuously made effort to pay ransom for Catherine. In 1474, Sigismund's mother travelled to the Ottoman border wishing to make contact with her half-brother, Hersekzade Ahmed Pasha, who had converted to Islam and become an Ottoman statesman.

The plan failed, however. Sigismund took part in the Battle of Otlukbeli as member of Mehmed's retinue, which saw the Ottoman victory over Uzun Hassan, in 1473, he was notably close to the Sultan. Together they dined and played backgammon, with Sigismund becoming upset during the game and entertaining Mehmed with his "crude jests". Around 1475, when the last attempt of his mother to pay ransom for him failed, Sigismund converted from Roman Catholicism to Islam and became known as Ishak Bey the King's Son, he was Muslim by the time the Ottomans enthroned his cousin Matthias as puppet king of Bosnia, in the spring of 1476, as otherwise he would have been considered for the post. Shortly before her death, in October 1478, Queen Catherine devised a will by which she named Sigismund heir to the Bosnian throne on the condition of converting back to Christianity. Ishak Bey served under his uncle Ahmed Pasha and his quick advance in military career continued during the reign of Mehmed's son and successor, Bayezid II.

He rose to the post of sanjak-bey of Karasi in Anatolia and took part in the Ottoman–Mamluk War, fighting first under Hadım Yakup Pasha and with his uncle near Adana. Ahmed Pasha and Ishak Bey were defeated and captured by the Mamluk army along with other Ottoman sanjak-beys in 1486. Ishak was freed from Egypt by 17 August 1488, when he participated in another unsuccessful battle against the Mamluks. Having been part of the right flank, which left the battlefield early and contributed to the loss, Ishak Bey was judged and acquitted. Ishak was last mentioned as recounting the events of the Battle of Krbava Field, which took place on 9 September 1493 and in which the Ottoman army was victorious. Ishak Bey was the last known member of the House of Kotromanić. Babinger, Franz. Mehmed the Conqueror and His Time. Princeton University Press. ISBN 0-691-01078-1. Draganović, Povijest hrvatskih zemalja Bosne i Hercegovine od najstarijih vremena do godine 1463, HKD Napredak Pandžić, Bazilije, "Katarina Vukčić Kosača", Povijesnoteološki simpozij u povodu 500 obljetnice smrti bosanske kraljice Katarine, Franjevačka teologija u Sarajevu Regan, Krešimir, Bosanska kraljica Katarina, Breza

Pedro de Madrazo y Kuntz was a Spanish painter, writer and art critic. He came from an illustrious family of artists, his father was the painter José de Madrazo y Agudo and his mother, Isabel Kuntz Valentini, was a daughter of the Polish painter, Tadeusz Kuntze. Two of his brothers, Federico de Madrazo and Luis de Madrazo were painters, his sister, married the editor of the journal, El Artista, Eugenio de Ochoa. He and his brother Federico were born in Rome, while their father was studying there on a grant from King Charles IV, his primary education began at a seminary school operated by the Jesuits. This was followed by legal studies in Toledo and at the University of Valladolid, where he graduated. In 1837, he and Federico traveled to Paris back to Rome. Shortly after, he married daughter of the painter, Eduardo Rosales, they had a son. During this time, he worked as an art teacher, he moved to Madrid. There, he, his brother Federico and future brother-in-law, created the magazine, El Artista, which played a major role in establishing the Romantic style in Spain.

He contributed to most of the cultural publications of the day. He served as Editor of El Domingo, where he published verses in imitation of the Psalms and translations from the Bible, he combined his journalistic career with legal service. From 1870-1871 and again from 1875-1880, he was that body's Secretary General. In 1888, he was a Minister with the "Tribunal de lo Contencioso Administrativo", he retired from his legal activities in 1897. Progressive in his youth, he became more conservative with age and, during the Restoration, belonged to the Conservative Party of Antonio Cánovas del Castillo. In his role of art critic and historian, he promoted Gothic art as the most representative style and introduced the concept of art as an historical heritage, he chaired a commission on the preservation of provincial historical monuments and wrote the catalogues for the Museo del Prado. As a writer, he favored lyric poetry with a religiously moral emphasis and some patriotism, he penned two theatrical pieces, a number of Cuadros de costumbres and some travel pieces.

His major translations include Criminal Law and Political Economy, by Pellegrino Rossi, the Book of Orators, by Joseph-Marie Timon-David and History of the Consulate and Empire, by Adolphe Thiers. In his life, he became Director of the Museo de Arte Moderno and, in 1894, succeeded his brother Federico as Director of the Real Academia de Bellas Artes de San Fernando, of which he had been a member since 1851, he was a member of the Real Academia Española and the Real Academia de la Historia, where he served as Secretary. He held honorary memberships in several institutions outside Spain. Francisco Calvo Serraller, "Pedro de Madrazo, historiador y crítico de arte", in, Los Madrazo, una familia de artistas, Museo Municipal, 1985 Enrique Pardo Canalís, "Pedro de Madrazo", in, Revista de Ideas Estéticas, vol. XXXIV, Madrid, 1951, p. 175. Javier Portús Pérez, Pedro de Enciclopedia del Museo del Prado, FAMP

Lino Martschini is a Swiss professional ice hockey forward for EV Zug of the National League and the Swiss national team. He played his junior hockey for the Peterborough Petes of the Ontario Hockey League. Prior to coming to Peterborough, Ontario, to play for the Peterborough Petes, Martschini was a successful player with many teams in Zug, playing in Top Mini, Elite Novizen, Elite Jr. A, Top Junioren leagues with teams varying from under-15 to under-20, he represented his country, Switzerland, in various junior world championships, before being drafted in the 2010 CHL Import Draft by the Petes. When he arrived in the OHL for the 2010–11 season, Martschini was a top player for the Petes, notching 20 goals and 38 assists for a total of 58 points in 61 games, just shy of a point-per-game, he had only 12 penalty minutes, but was a -35. He was one of the Petes' top players and put out an excellent showing as a rookie on a team that boasted players like Matt Puempel and Ryan Spooner. Both were selected in the 2011 NHL Entry Draft, by the Ottawa Senators and Boston Bruins but Martschini was passed over.

He returned to Peterborough for 2011–12. Playing in 63 games as a 19-year-old, he notched 21 goals and 35 assists for 56 points, along with eight penalty minutes and a -13; this would be his last year playing in the OHL. Martschini left for his native country to play for EV Zug in the National League A, for the 2012–13, he played well in his limited time, putting up 13 assists for a total of 30 points. He was a +5 rating, for an excellent rookie season. In the 2013–14, Martschini played more games, but was only able to score 27 points in 50 games in his sophomore year, with just two penalty minutes and a +3. Prior to the 2015–16 season, Martschini agreed to a four-year contract extension with EV Zug worth CHF 2.5 million. At the end of the 2015-16 season, he was selected to play in the 2016 World Championship with the Swiss national team, he played 4 of the team's 7 games. On August 23, 2019, Martschini was signed to an early three-year contract extension by Zug worth CHF 2.175 million through the 2022/23 season.

Biographical information and career statistics from Eliteprospects.com, or The Internet Hockey Database

Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin-norepinephrine reuptake inhibitor class. It is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, social phobia, it may be used for chronic pain. It is taken by mouth. Common side effects include loss of appetite, dry mouth, dizziness and sexual problems. Severe side effects include an increased risk of suicide and serotonin syndrome. Antidepressant withdrawal syndrome may occur. There are concerns that use during the part of pregnancy can harm the baby. How it works is not clear but it is believed to involve alterations in neurotransmitters in the brain. Venlafaxine was approved for medical use in the United States in 1993, it is available as a generic medication. In the United States the wholesale cost per dose is less than US$0.20 as of 2018. In 2016 it was the 51st most prescribed medication in the United States with more than 15 million prescriptions.

Venlafaxine is used for the treatment of depression, general anxiety disorder, social phobia, panic disorder, vasomotor symptoms. Venlafaxine has been used off label for the treatment of diabetic neuropathy and migraine prevention, it may work on pain via effects on the opioid receptor. It has been found to reduce the severity of'hot flashes' in menopausal women and men on hormonal therapy for the treatment of prostate cancer. Due to its action on both the serotoninergic and adrenergic systems, venlafaxine is used as a treatment to reduce episodes of cataplexy, a form of muscle weakness, in patients with the sleep disorder narcolepsy; some open-label and three double-blind studies have suggested the efficacy of venlafaxine in the treatment of attention deficit-hyperactivity disorder. Clinical trials have found possible efficacy in those with post-traumatic stress disorder. A comparative meta-analysis of 21 major antidepressants found that venlafaxine, amitriptyline, mirtazapine and vortioxetine were more effective than other antidepressants although the quality of many comparisons was assessed as low or low.

Venlafaxine was similar in efficacy to the atypical antidepressant bupropion. In a double-blind study, patients who did not respond to an SSRI were switched to venlafaxine or citalopram. Similar improvement was observed in both groups. Studies of venlafaxine in children have not established its efficacy. Venlafaxine is not recommended in patients hypersensitive to it, nor should it be taken by anyone, allergic to the inactive ingredients, which include gelatin, ethylcellulose, iron oxide, titanium dioxide and hypromellose, it should not be used in conjunction with a monoamine oxidase inhibitor, as it can cause fatal serotonin syndrome. Venlafaxine can increase eye pressure, so those with glaucoma may require more frequent eye checks; the US Food and Drug Administration body requires all antidepressants, including venlafaxine, to carry a black box warning with a generic warning about a possible suicide risk. A 2014 meta analysis of 21 clinical trials of venlafaxine for the treatment of depression in adults found that compared to placebo, venlafaxine reduced the risk of suicidal thoughts and behavior.

A study conducted in Finland followed more than 15,000 patients for 3.4 years. Venlafaxine increased suicide risk by 60%, as compared to no treatment. At the same time, fluoxetine halved the suicide risk. In another study, the data on more than 200,000 cases were obtained from the UK general practice research database. At baseline, patients prescribed venlafaxine had a greater number of risk factors for suicide than patients treated with other anti-depressants; the patients taking venlafaxine had higher risk of completed suicide than the ones on fluoxetine or citalopram. After adjusting for known risk factors, venlafaxine was associated with an increased risk of suicide relative to fluoxetine and dothiepin, not statistically significant. A statistically significant greater risk for attempted suicide remained after adjustment, but the authors concluded that it could be due to residual confounding. An analysis of clinical trials by the FDA statisticians showed the incidence of suicidal behaviour among the adults on venlafaxine to be not different from fluoxetine or placebo.

Venlafaxine is contraindicated in children and young adults. According to the FDA analysis of clinical trials venlafaxine caused a statistically significant 5-fold increase in suicidal ideation and behaviour in persons younger than 25. In another analysis, venlafaxine was no better than placebo among children, but improved depression in adolescents. However, in both groups and suicidal behaviour increased in comparison to those receiving a placebo. In a study involving antidepressants that had failed to produce results in depressed teenagers, teens whose SSRI treatment had failed who were randomly switched to either another SSRI or to venlafaxine showed an increased rate of suicide on venlafaxine. Among teenagers who were suicidal at the beginning of the study, the rate of suicidal attempts and self-harm was higher, by about 60%, after the switch to venlafaxine than after the switch to an SSRI. People stopping venlafaxine experience discontinuation symptoms such as dysphoria, nausea, emotional lability, sensation of electric shocks, sleep disturbance.

Venlafaxine has a higher ra

Alfred Buckwalter Garner was a Republican member of the U. S. House of Representatives from Pennsylvania. Alfred B. Garner was born in Pennsylvania, he was admitted to the bar in 1897 and commenced practice in Ashland. He served as a member of the Pennsylvania State House of Representatives from 1901 to 1907. Garner was elected as a Republican to the Sixty-first Congress, he was again a member of the State House of Representatives from 1915 to 1917. He resumed the practice of law in Ashland and served as the taxing officer of the auditor general’s department in Harrisburg, until his death in Harrisburg, he was interred at Fountain Spring Cemetery in Pennsylvania. United States Congress. "Alfred B. Garner". Biographical Directory of the United States Congress; the Political Graveyard Alfred Buckwalter Garner at Find a Grave