Tillabéri is one of the seven Regions of Niger; the capital of the Region is Tillabéri. Tillabéri Region was created in 1992, when Niamey Region was split, with Niamey and its immediate hinterland becoming a new capital district enclaved within Tillabéri Region.

Niamey is the capital and largest city of Niger. Niamey lies on the Niger River, primarily situated on the east bank. Niamey's population was counted as 1,026,848 as of the 2012 census. As of 2017, population projections show the capital district growing at a slower rate than the country as a whole, which has the world's highest fertility rate. The city is located in a pearl millet growing region, while manufacturing industries include bricks, ceramic goods, cement, and weaving.