Time 100 is a list of the top 100 most influential people in the world, assembled by the American news magazine Time. First published in 1999 as the result of a debate among American academics, politicians, and journalists, the list is now a highly publicized annual event. Appearing on the list is often seen as an honor, and Time makes it clear that entrants are recognized for changing the world, regardless of the consequences of their actions. The final list of influential individuals is exclusively chosen by Time editors, with nominations coming from the Time 100 alumni and the magazine's international writing staff. Only the winner of the Reader's Poll, conducted days before the official list is revealed, is chosen by the general public. The corresponding commemorative gala is held annually in Manhattan.

Ali al-Husayni al-Sistani is an Iranian-Iraqi Islamic scholar. One of the most senior scholars of Twelver Shia with the rank of Grand Ayatollah and marja', he has been described as the spiritual leader of Shia Muslims worldwide, "the undisputed leader of Iraq's Shias", included in top positions of "The Muslim 500: The World's Most Influential Muslims", from 2009 to 2023, and named one of the 100 most influential people in the world by Time magazine in 2004 and 2005.