Tisbury is a town located on Martha's Vineyard in Dukes County, Massachusetts, United States. The population was 4,815 at the 2020 census.

Martha's Vineyard, often simply called the Vineyard, is an island in the Northeastern United States, south of Cape Cod in Dukes County, Massachusetts, known for being a popular, affluent summer colony. Martha's Vineyard includes the smaller adjacent Chappaquiddick Island, a peninsula, currently connected to the Vineyard. It is the 58th largest island in the U.S., with a land area of about 96 square miles (250 km2), and the third-largest on the East Coast, after Long Island and Mount Desert Island. Martha's Vineyard constitutes the bulk of Dukes County, which also includes the Elizabeth Islands and the island of Nomans Land.