Tisiphone, or Tilphousia, was one of the three Erinyes or Furies. Her sisters were Alecto and Megaera. She and her sisters punished crimes of murder: parricide, fratricide and homicide.

The Erinyes, also known as the Eumenides, are chthonic goddesses of vengeance in ancient Greek religion and mythology. A formulaic oath in the Iliad invokes them as "the Erinyes, that under earth take vengeance on men, whosoever hath sworn a false oath". Walter Burkert suggests that they are "an embodiment of the act of self-cursing contained in the oath". They correspond to the Dirae in Roman mythology. The Roman writer Maurus Servius Honoratus wrote that they are called "Eumenides" in hell, "Furiae" on Earth, and "Dirae" in heaven. Erinyes are akin to some other Greek deities, called Poenai.