Tláhuac is a borough in the Mexico City, located in the southeastern edge of the entity. Though Tláhuac still contains rural communities within its borders, mostly in the southern and eastern portions, the borough has undergone a massive shift from urbanization, especially in its northwest. Tláhuac has experienced the fastest rate of population growth in Mexico City since the 1960s.

Iztapalapa is a borough in Mexico City, located on the east side of the entity. The borough is named after and centered on the formerly independent municipality of Iztapalapa, which is officially called Iztapalapa de Cuitláhuac for disambiguation purposes. The rest is made up of a number of other communities which are governed by the city of Iztapalapa.