Tlacotalpan is a municipality located in the eastern coastal region of the Mexican state of Veracruz. It covers a total surface area of 646.51 km2 (250 sq mi), accounting for 0.89% of the state total. The municipal seat is the city of Tlacotalpan, Veracruz, a UNESCO World Heritage Site.

Veracruz is a state in central eastern Mexico that is divided into 212 municipalities. According to the 2020 Mexican census, it is the fourth most populated state with 8,062,579 inhabitants and the 11th largest by land area spanning 71,823.5 square kilometres (27,731.2 sq mi).