Tlaltenango de Sánchez Román is a municipality located in the southwestern portion of the Mexican state of Zacatecas. The average elevation of the municipality is 1,723 meters (5,653 ft) above sea level and the municipality covers an area of 808.082 square kilometres (312.002 sq mi). The municipality lies in a valley bordered by the Sierra de Morones and lies on the banks of the Tlaltenango River, which runs north and is a tributary of the Bolaños River.

Zacatecas ( ), officially the Free and Sovereign State of Zacatecas, is one of the 31 states of Mexico. It is divided into 58 municipalities and its capital city is Zacatecas.